Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition

Endogenously synthesized n-3 polyunsaturated fatty acids in fat-1 transgenic mice suppress B16F10 melanoma lung metastasis by impairing mesenchymal to epithelial transition

Malignant melanoma is an aggressive cancer of neuroectodermal origin. The mechanisms of n-3 polyunsaturated fatty acids (PUFAs) against melanoma metastasis are not clear. Here fat-1 and wild type (WT) mice were injected with B16F10 melanoma cells via the tail vein to establish lung metastasis model....

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Bibliographic Details
Main Authors: Pan Zhu, Yuan-Ming Zhang, Xuan Yin, Xiao-Hong Zhang, Feng Wang, Jin-Jie Zhang, Wang Yan, Yang Xi, Jian-Bo Wan, Jing-Xuan Kang, Zu-Quan Zou, Shi-Zhong Bu
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Journal of Functional Foods
Subjects:
Fat-1
n-3 polyunsaturated fatty acids
Mesenchymal to epithelial transition
Lipid mediators
IL-1β
Melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S175646461630319X

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http://www.sciencedirect.com/science/article/pii/S175646461630319X

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