Virilizing adrenocortical oncocytoma in a toddler

• Main Authors: Merna El Khansa, Amal Naous, Nabil Daoud, Mariam El Rajab
• Format: Article
• Language: English
• Published: Elsevier 2017-12-01
• Series: Journal of Pediatric Surgery Case Reports
• Subjects: Adrenal cortex neoplasms; Adrenal oncocytoma; Hirsutism; Virilism
• Online Access: http://www.sciencedirect.com/science/article/pii/S2213576617302221

Functioning adrenocortical oncocytomas are extremely rare and most reported patients are 40–60 yr of age. To our knowledge, only 6 cases of functioning adrenocortical oncocytomas have been reported in childhood. We report a case of functioning adrenocortical oncocytoma in a 3 year 4 month-old female child presenting with hirsutism, acne and virilization. She presented with coarse features, deepening of the voice and excessive hair growth, and elevation of plasma testosterone and dehydroepiandrosterone sulfate. She had an adrenalectomy. The completely resected tumor composed predominantly of oncocytes without atypical mitosis and necrosis. A discussion of this case and a review of the literature on this entity are presented.