Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction

• Main Authors: Lu Zhang, Fang Li, Xiaomin Su, Yue Li, Yining Wang, Ruonan Fang, Yingying Guo, Tongzhu Jin, Huitong Shan, Xiaoguang Zhao, Rui Yang, Hongli Shan, Haihai Liang
• Format: Article
• Language: English
• Published: Nature Publishing Group 2019-07-01
• Series: Experimental and Molecular Medicine
• Online Access: https://doi.org/10.1038/s12276-019-0273-8

Lung disease: managing misbehaving mitochondria The hormone melatonin could protect lung cells from the damage associated with respiratory diseases such as pulmonary fibrosis. Several studies have linked such damage with abnormal activity of the mitochondria, with these essential metabolic organelles churning out damaging ‘reactive oxygen species’ (ROS), compounds that induce premature cell aging and death. Melatonin can mitigate ROS production, and researchers led by Haihai Liang at China’s Harbin Medical University have demonstrated that it can prevent injury to airway epithelial cells in a mouse model of lung disease. Melatonin treatment countered much of the damage, resulting in significantly longer survival, and the team identified a target molecule in the mitochondria that may be responsible for this effect. This approach could offer hope for a family of diseases with a poor prognosis and limited treatment options.