TCR signal strength alters T-DC activation and interaction times and directs the outcome of differentiation.
The ability of CD4+ T cells to differentiate into effector subsets underpins their ability to shape the immune response and mediate host protection. During T cell receptor induced activation of CD4+ T cells both the quality and quantity of specific activatory peptide/MHC ligands have been shown to c...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00006/full |