Elevated extracellular CO<sub>2</sub> level affects the adaptive transcriptional response and survival of human peripheral blood mononuclear cells toward hypoxia and oxidative stress

Elevated extracellular CO<sub>2</sub> level affects the adaptive transcriptional response and survival of human peripheral blood mononuclear cells toward hypoxia and oxidative stress

BACKGROUND High carbon dioxide (CO2) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2 level increases CO2 level in the blood, and over-accumulation of CO2 induces an adaptive response that requires modulation of gene expression...

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Bibliographic Details
Main Authors: Septelia Inawati Wanandi, Sekar Arumsari, Edwin Afitriansyah, Resda Akhra Syahrani, Idham Rafly Dewantara, Luthfian Aby Nurachman, Ihya Fakhrurizal Amin, Putera Dewa Haryono, Kenny Budiman, Adrianus Jonathan Sugiharta, Amino Aytiwan Remedika, Farhan Hilmi Tafikulhakim, Febriana Catur Iswanti, Jason Youngbin Lee, Debabrata Banerjee
Format: Article
Language:English
Published: Faculty of Medicine Universitas Indonesia 2021-03-01
Series:Medical Journal of Indonesia
Subjects:
elevated CO2
extracelullar pH
oxidative stress
PBMC
reactive oxygen species
Online Access:https://mji.ui.ac.id/journal/index.php/mji/article/view/3810

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