Efficacy of minute virus of mice (MVM) inactivation utilizing high temperature short time (HTST) pasteurization and suitability assessment of pasteurized, concentrated glucose feeds in Chinese hamster ovary (CHO) cell expression systems

Abstract There is a growing need to provide effective adventitious agent mitigation for high risk upstream cell culture raw materials used for the production of biologics. It is also highly important in the growing fields of cell and gene therapies. Glucose is a critical raw material necessary for e...

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Bibliographic Details
Main Authors: David K. Gemmell, Aaron Mack, Sabrina Wegmann, David Han, Ronald Tuccelli, Matthew Johnson, Corinne Miller
Format: Article
Language:English
Published: Wiley-VCH 2021-07-01
Series:Engineering in Life Sciences
Subjects:
Online Access:https://doi.org/10.1002/elsc.202100044