FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury

FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury

The alveolar epithelium secretes cytokines and chemokines that recruit immune cells to the lungs, which is essential for fighting infections but in excess can promote lung injury. Overexpression of FXYD5, a tissue-specific regulator of the Na,K-ATPase, in mice, impairs the alveolo-epithelial barrier...

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Bibliographic Details
Main Authors: Patricia L. Brazee, Pritin N. Soni, Elmira Tokhtaeva, Natalia Magnani, Alex Yemelyanov, Harris R. Perlman, Karen M. Ridge, Jacob I. Sznajder, Olga Vagin, Laura A. Dada
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
alveolar epithelium
inflammation
FXYD5
acute lung injury
C-C chemokine ligand-2
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00623/full

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