A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest

A comparison of LKB1/AMPK/mTOR metabolic axis response to global ischaemia in brain, heart, liver and kidney in a rat model of cardiac arrest

Abstract Background Cellular energy failure in high metabolic rate organs is one of the underlying causes for many disorders such as neurodegenerative diseases, cardiomyopathies, liver and renal failures. In the past decade, numerous studies have discovered the cellular axis of LKB1/AMPK/mTOR as an...

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Bibliographic Details
Main Authors: Shohreh Majd, John H. T. Power, Timothy K. Chataway, Hugh J. M. Grantham
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Cell Biology
Subjects:
Cell energy stress
ADP/ATP
Ischaemia
Liver kinase b1
LKB
Adenosine monophosphate kinase protein kinase
Online Access:http://link.springer.com/article/10.1186/s12860-018-0159-y

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http://link.springer.com/article/10.1186/s12860-018-0159-y

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