Pausing controls branching between productive and non-productive pathways during initial transcription in bacteria
RNA synthesis by bacterial RNA polymerase is interrupted by pauses but their role in RNA synthesis is poorly understood. Here the authors use single-molecule FRET and biochemical analysis to show that pausing regulates branching between the abortive and productive outcomes of initial transcription.
Bibliographic Details
| Main Authors: |
David Dulin,
David L. V. Bauer,
Anssi M. Malinen,
Jacob J. W. Bakermans,
Martin Kaller,
Zakia Morichaud,
Ivan Petushkov,
Martin Depken,
Konstantin Brodolin,
Andrey Kulbachinskiy,
Achillefs N. Kapanidis |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2018-04-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-03902-9
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