Clinical study about the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Sch觟enlein purpura

• Main Authors: Hua Li1, Hong Zhang2
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-05-01
• Series: Journal of Hainan Medical University
• Subjects: Henoch-Schöenlein purpura Helicobacter pylori Renal function Immune response
• Online Access: http://www.hnykdxxb.com/PDF/201709/21.pdf

Objective: To study the effect of Helicobacter pylori infection on renal function and immune response in children with Henoch-Schöenlein purpura (HSP). Methods: Children diagnosed with Henoch-Schöenlein purpura in Zhognshan Chenxinghai Hospital and Huizhou Third People’s Hospital between May 2013 and July 2016 were selected and divided into Hp(﹢) and Hp(-) HSP group according to Helicobacter pylori infection condition. Then renal function and immune response were determined. Results: Scr, BUN, CysC, TM, vWF, sVCAM-1, CTGF, MMP9, IL-17 and IL-23 contents in serum as well as Th17 cell content in peripheral blood of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, Treg cell content in peripheral blood as well as TGF-β1 and IL-10 contents in serum of Hp(﹢) HSP group were significantly lower than those of Hp(-) HSP group, SOCS1 and Tim1 mRNA expression in peripheral blood mononuclear cells of Hp(﹢) HSP group were significantly higher than those of Hp(-) HSP group, and SOCS3 and Tim3 mRNA expression were not significantly different from those of Hp(-) HSP group. Conclusion: Helicobacter pylori infection in children with Henoch-Schöenlein purpura can aggravate the damage of renal function and the disorder of autoimmune response.