Clinical Features and MicroRNA Expression Patterns Between AML Patients With DNMT3A R882 and Frameshift Mutations

Clinical Features and MicroRNA Expression Patterns Between AML Patients With DNMT3A R882 and Frameshift Mutations

Background: DNA methyltransferase 3A (DNMT3A) plays a unique role in hematopoiesis and acute myeloid leukemia (AML) pathogenesis. While the influences of DNMT3A mutation subtypes are still under debate.Purpose: Exploration of the clinical and molecular differences between AML patients carrying DNMT3...

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Bibliographic Details
Main Authors: Li Yang, Ke'Feng Shen, Mei'Lan Zhang, Wei Zhang, Hao'Dong Cai, Li'Man Lin, Xiao'Lu Long, Shu'Gang Xing, Yang Tang, Jie Xiong, Jia'Chen Wang, Deng'Ju Li, Jian'Feng Zhou, Min Xiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
leukemia
DNMT3A gene mutations
microRNA
expression
clinical
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01133/full

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