2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels

2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels

Targeted delivery of therapeutic compounds to particular cell types such that they only affect the target cells is of great clinical importance since it can minimize undesired side effects. For example, typical chemotherapeutic treatments used in the treatment of neoplastic disorders are cytotoxic n...

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Bibliographic Details
Main Authors: Hagit Neumann-Raizel, Asaf Shilo, Shaya Lev, Maxim Mogilevsky, Ben Katz, David Shneor, Yoav D. Shaul, Andreas Leffler, Alberto Gabizon, Rotem Karni, Alik Honigman, Alexander M. Binshtok
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
TRPV2 channels
targeted delivery
hepatocellular carcinoma
BNL1 ME cells
membrane permeation
doxorubicin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01198/full

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