Effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke
Objective: To study the effects of dexzopiclone and estazolam on neurotransmitters, nerve cytokines and stress states in patients with insomnia after stroke. Methods: The patients with insomnia after stroke who were treated in Linyi Rongjun Hospital between March 2015 and October 2017 were chosen...
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-11-01
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| Series: | Journal of Hainan Medical University |
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| Online Access: | http://www.hnykdxxb.com/PDF/201811/20.pdf |
| Summary: | Objective: To study the effects of dexzopiclone and estazolam on neurotransmitters, nerve
cytokines and stress states in patients with insomnia after stroke. Methods: The patients with
insomnia after stroke who were treated in Linyi Rongjun Hospital between March 2015 and
October 2017 were chosen and randomly divided into dexzopiclone group and estazolam
group. The levels of neurotransmitters, nerve cytokines and stress indexes in serum were
measured before treatment as well as 14 days and 28 days after treatment. Results: Compared
with those before treatment, serum Glu, γ-GABA, 5-HT, 5-HIAA, BDNF and NGF levels
of both groups significantly increased whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD
and GSH levels significantly decreased after treatment, and serum Glu, γ-GABA, 5-HT,
5-HIAA, BDNF and NGF levels of dexzopiclone group after treatment were higher than
those of estazolam group whereas NE, TNF-α, IL-6, ATCH, Cor, CRP, SOD and GSH levels
were lower than those of estazolam group. Conclusion: Dexzopiclone is more effective than
estazolam to regulate the secretion of neurotransmitters and nerve cytokines and reduce the
stress state in patients with insomnia after stroke. |
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| ISSN: | 1007-1237 1007-1237 |