Targeting targeted agents: open issues for clinical trial design

Targeting targeted agents: open issues for clinical trial design

<p>Abstract</p> <p>Molecularly targeted agents for the treatment of solid tumors had entered the market in the last 5 years, with a great impact upon both the scientific community and the society. Many randomized phase III trials conducted in recent years with new targeted agents,...

Full description

Bibliographic Details
Main Authors:	Giannarelli Diana, Cuppone Federica, Carlini Paolo, Di Maio Massimo, Bria Emilio, Cognetti Francesco, Milella Michele
Format:	Article
Language:	English
Published:	BMC 2009-05-01
Series:	Journal of Experimental & Clinical Cancer Research
Online Access:	http://www.jeccr.com/content/28/1/66

Similar Items

Magnitude of benefit of the addition of bevacizumab to first-line chemotherapy for metastatic colorectal cancer: meta-analysis of randomized clinical trials
by: Falcone Alfredo, et al.
Published: (2010-05-01)

Impact of hormonal treatment duration in combination with radiotherapy for locally advanced prostate cancer: Meta-analysis of randomized trials
by: Pinnarò Paola, et al.
Published: (2010-12-01)

Magnitude of risks and benefits of the addition of bevacizumab to chemotherapy for advanced breast cancer patients: Meta-regression analysis of randomized trials
by: Russillo Michelangelo, et al.
Published: (2011-05-01)

Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy
by: Italia Falcone, et al.
Published: (2020-10-01)

Maintenance therapy in NSCLC: why? To whom? Which agent?
by: Maione Paolo, et al.
Published: (2011-05-01)

Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers.
by: Luisa Carbognin, et al.
Published: (2015-01-01)

Role of mTOR Signaling in Tumor Microenvironment: An Overview
by: Fabiana Conciatori, et al.
Published: (2018-08-01)

mTOR Cross-Talk in Cancer and Potential for Combination Therapy
by: Fabiana Conciatori, et al.
Published: (2018-01-01)

AXL Receptor in Breast Cancer: Molecular Involvement and Therapeutic Limitations
by: Italia Falcone, et al.
Published: (2020-11-01)

Open-target sparse sensing of biological agents using DNA microarray
by: Skaer Haley B, et al.
Published: (2011-07-01)

Open-target sparse sensing of biological agents using DNA microarray
by: Mohtashemi, Mojdeh, et al.
Published: (2012)

Validation of synthetic lethal hits of microtubule targeting agents
by: Di Lalla, Matthew
Published: (2021)

Addressing the Issue of Tetrodotoxin Targeting
by: Daria I. Melnikova, et al.
Published: (2018-09-01)

Molecular Targets of TRAIL-Sensitizing Agents in Colorectal Cancer
by: Giovanni Monteleone, et al.
Published: (2012-06-01)

Literature evidence in open targets - a target validation platform
by: Şenay Kafkas, et al.
Published: (2017-06-01)

Targeted Therapy: Attacking Cancer with Molecular and Immunological Targeted Agents
by: Gail M Wilkes
Published: (2018-01-01)

Reliability Assessment of Passive Safety Systems for Nuclear Energy Applications: State-of-the-Art and Open Issues
by: Francesco Di Maio, et al.
Published: (2021-08-01)

Targeted Agents in Ovarian Carcinoma
by: Murat Oz, et al.
Published: (2016-06-01)

Anticancer Agents Targeted to Sirtuins
by: Tomohiro Kozako, et al.
Published: (2014-12-01)

Targeted delivery of biological agents
by: Greig, Jenny A.
Published: (2009)

Advances in Tumor-Stroma Interactions: Emerging Role of Cytokine Network in Colorectal and Pancreatic Cancer
by: Chiara Bazzichetto, et al.
Published: (2019-01-01)

Editorial for Special Issue “Remote Sensing for Target Object Detection and Identification”
by: Gemine Vivone, et al.
Published: (2020-01-01)

PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target
by: Lisa Salvatore, et al.
Published: (2019-11-01)

Symmetry issues in Directly Irradiated Targets
by: Ramis R., et al.
Published: (2013-11-01)

Targeting Polymorphonuclear Leukocytes in Acute Myocardial Infarction
by: Clara Di Filippo, et al.
Published: (2007-01-01)

Optimal inflation target: insights from an agent-based model
by: Jean-Philippe Bouchaud, et al.
Published: (2018-03-01)

Optimal inflation target: insights from an agent-based model
by: Jean-Philippe Bouchaud, et al.
Published: (2017-09-01)

Challenges of clinical trial design for targeted agents against pediatric leukemias
by: Francis Jay Mussai, et al.
Published: (2015-01-01)

Thyroid Dysfunction with Targeted Chemotherapy Agents
by: Bossaer, John B.
Published: (2012)

Bone-targeted agents in multiple myeloma
by: Hiroko Nishida
Published: (2018-03-01)

Nonimmunologic targets of immunosuppressive agents in podocytes
by: Tae-Hyun Yoo, et al.
Published: (2015-06-01)

Antineoplastic Agents Targeting Sphingolipid Pathways
by: Alexander Kroll, et al.
Published: (2020-05-01)

Natural Agents Targeting Mitochondria in Cancer
by: Shalini Mani, et al.
Published: (2020-09-01)

Rational Combinations of Targeted Agents in AML
by: Prithviraj Bose, et al.
Published: (2015-04-01)

Novel targeted agents for gastric cancer
by: Liu Lian, et al.
Published: (2012-06-01)

Targeted agents for the treatment of metastatic melanoma
by: Monzon JG, et al.
Published: (2012-03-01)

Circular RNAs as Therapeutic Agents and Targets
by: Lesca M. Holdt, et al.
Published: (2018-10-01)

Multi-Agent Cooperative Target Search
by: Jinwen Hu, et al.
Published: (2014-05-01)

Targeted Contrast Agents for Molecular MRI
by: Sara Lacerda
Published: (2018-12-01)

The development of novel cancer targeting agents
by: Knoetze, Steyn
Published: (2011)