Anti-inflammatory effects of saxagliptin and vildagliptin against doxorubicin-induced nephrotoxicity in rats: attenuation of NLRP3 inflammasome up-regulation and tubulo-interstitial injury

Anti-inflammatory effects of saxagliptin and vildagliptin against doxorubicin-induced nephrotoxicity in rats: attenuation of NLRP3 inflammasome up-regulation and tubulo-interstitial injury

Background and purpose: The clinical use of the chemotherapeutic drug, doxorubicin (DXR), is significantly limited by its extensive multi-organ toxicity. Dipeptidyl peptidase-4 (DPP4) is over-expressed in oxidative stress, inflammation and apoptosis. DPP4 inhibitors have proven pleiotropic effects....

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Bibliographic Details
Main Authors: Rasha Ezzat Mostafa, Azza Hassan Morsi, Gihan Farag Asaad
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
doxorubicin; saxagliptin; vildagliptin; nephrotoxicity; inflammation; tubulo-interstitial injury.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2021;volume=16;issue=5;spage=547;epage=558;aulast=Mostafa

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