Non-additive genetic effects for fertility traits in Canadian Holstein cattle (<it>Open Access publication </it>)

• Main Authors: Miglior Filippo, Schaeffer Lawrence R, Palucci Valentina, Osborne Vern
• Format: Article
• Language: deu
• Published: BMC 2007-02-01
• Series: Genetics Selection Evolution
• Subjects: fertility; gene interactions; dairy cattle; non-additive models
• Online Access: http://www.gse-journal.org/content/39/2/181
• ISSN: 0999-193X; 1297-9686

<p>Abstract</p> <p>The effects of additive, dominance, additive by dominance, additive by additive and dominance by dominance genetic effects on age at first service, non-return rates and interval from calving to first service were estimated. Practical considerations of computing additive and dominance relationships using the genomic relationship matrix are discussed. The final strategy utilized several groups of 1000 animals (heifers or cows) in which all animals had a non-zero dominance relationship with at least one other animal in the group. Direct inversion of relationship matrices was possible within the 1000 animal subsets. Estimates of variances were obtained using Bayesian methodology <it>via </it>Gibbs sampling. Estimated non-additive genetic variances were generally as large as or larger than the additive genetic variance in most cases, except for non-return rates and interval from calving to first service for cows. Non-additive genetic effects appear to be of sizeable magnitude for fertility traits and should be included in models intended for estimating additive genetic merit. However, computing additive and dominance relationships for all possible pairs of individuals is very time consuming in populations of more than 200 000 animals.</p>