A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy

Epidermolytic palmoplantar keratoderma (EPPK) is a relatively common autosomal-dominant skin disorder caused by mutations in the keratin 9 gene (KRT9), with few therapeutic options for the affected so far. Here, we report a knock-in transgenic mouse model that carried a small insertion–deletion (ind...

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Bibliographic Details
Main Authors: Ya-Su Lyu, Pei-liang Shi, Xiao-Ling Chen, Yue-Xiao Tang, Yan-Fang Wang, Rong-Rong Liu, Xiao-Rui Luan, Yu Fang, Ru-Huan Mei, Zhen-Fang Du, Hai-Ping Ke, Erik Matro, Ling-En Li, Zhao-Yu Lin, Jing Zhao, Xiang Gao, Xian-Ning Zhang
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
epidermolytic palmoplantar keratoderma
indel
knock-in
Krt9 gene (mouse)
shRNA therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300306

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