THE SYNTHESIS OF BIOCONJUGATE BASED ON RHENIUM(I) CARBONYL COMPLEX FOR VISUALIZATION OF PATHOLOGICAL PROCESS
Tricarbonyl rhenium(I) complexes have a great potential like biomarkers. It is caused their biological stability, low toxicity, large Stokes shifts, and long luminescence lifetimes. Rhenium tricarbonyl complexes fac-[Re(CO)3(N^N)], where N^N is a ligand with low π* orbitals are excellent candidates...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Odessa I. I. Mechnikov National University
2017-03-01
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| Series: | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ |
| Subjects: | |
| Online Access: | http://heraldchem.onu.edu.ua/article/view/94708 |
| Summary: | Tricarbonyl rhenium(I) complexes have a great potential like biomarkers. It is caused their biological stability, low toxicity, large Stokes shifts, and long luminescence lifetimes. Rhenium tricarbonyl complexes fac-[Re(CO)3(N^N)], where N^N is a ligand with low π* orbitals are excellent candidates as imaging dyes. The method of obtaining potential biomarkers based on tricarbonyl rhenium(I) complex with a 4-methyl-2,2’-bipyridine-4’-carboxylate by the addition of biomolecules by peptide synthesis was developed. The new complex [Re(CO)3MebpyCOOHBr] was synthesized, composition and structure of which were established by mass spectrometry, IR and NMR spectroscopy. A selective attachment of receptor peptide enkephalin to complex [Re(CO)3(MebpyCOOH)Br] was performed. The formation of a new compound and its structure has been confirmed by HPLC and mass spectral analysis. The method which has been developed allows to connect various peptides to rhenium(I) complex in the solution. |
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| ISSN: | 2304-0947 2414-5963 |