pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—tria...

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Main Authors: Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, Julia Poletaeva, Javier Sánchez-Nieves, Francisco Javier de la Mata, Rafael Gómez
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Nanomaterials
Subjects:
carbosilane
dendron
triazine
amphiphile
self-assembly
vesicles
Online Access:https://www.mdpi.com/2079-4991/10/10/1899
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spelling doaj-5a3758c891fc45118d6b5db38f2b460d2020-11-25T01:29:01ZengMDPI AGNanomaterials2079-49912020-09-01101899189910.3390/nano10101899pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug DeliveryEvgeny Apartsin0Nadezhda Knauer1Valeria Arkhipova2Ekaterina Pashkina3Alina Aktanova4Julia Poletaeva5Javier Sánchez-Nieves6Francisco Javier de la Mata7Rafael Gómez8Institute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaInstitute of Chemical Biology and Fundamental Medicine SB RAS, 8, Lavrentiev ave., 630090 Novosibirsk, RussiaDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, SpainDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, SpainDepartamento de Química Orgánica y Química Inorgánica, UAH-IQAR, Universidad de Alcalá, 28805 Alcalá de Henares, SpainSupramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.https://www.mdpi.com/2079-4991/10/10/1899carbosilanedendrontriazineamphiphileself-assemblyvesicles
collection DOAJ
language English
format Article
sources DOAJ
author Evgeny Apartsin
Nadezhda Knauer
Valeria Arkhipova
Ekaterina Pashkina
Alina Aktanova
Julia Poletaeva
Javier Sánchez-Nieves
Francisco Javier de la Mata
Rafael Gómez
spellingShingle Evgeny Apartsin
Nadezhda Knauer
Valeria Arkhipova
Ekaterina Pashkina
Alina Aktanova
Julia Poletaeva
Javier Sánchez-Nieves
Francisco Javier de la Mata
Rafael Gómez
pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
Nanomaterials
carbosilane
dendron
triazine
amphiphile
self-assembly
vesicles
author_facet Evgeny Apartsin
Nadezhda Knauer
Valeria Arkhipova
Ekaterina Pashkina
Alina Aktanova
Julia Poletaeva
Javier Sánchez-Nieves
Francisco Javier de la Mata
Rafael Gómez
author_sort Evgeny Apartsin
title pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_short pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_full pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_fullStr pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_full_unstemmed pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery
title_sort ph-sensitive dendrimersomes of hybrid triazine-carbosilane dendritic amphiphiles-smart vehicles for drug delivery
publisher MDPI AG
series Nanomaterials
issn 2079-4991
publishDate 2020-09-01
description Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
topic carbosilane
dendron
triazine
amphiphile
self-assembly
vesicles
url https://www.mdpi.com/2079-4991/10/10/1899
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