Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities

Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities

The heterogeneity of tumor cells and the potential existence of rare cells with reduced chemotherapeutic response is expected to play a pivotal role in the development of drug resistant cancers. Herein, we utilized the colon cancer cell lines, Caco2 and DLD1, to investigate heterogeneity of topoisom...

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Bibliographic Details
Main Authors: Cinzia Tesauro, Josephine Geertsen Keller, Irina Gromova, Pavel Gromov, Rikke Frohlich, Jens Uldum Erlandsen, Anni H. Andersen, Magnus Stougaard, Birgitta R. Knudsen
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
topoisomerase 1
colon cancer
phosphorylation
cell heterogeneity
camptothecin
Online Access:https://www.mdpi.com/2072-6694/12/5/1240

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