The Epigenome in Multiple Myeloma: Impact on Tumor Cell Plasticity and Drug Response

The Epigenome in Multiple Myeloma: Impact on Tumor Cell Plasticity and Drug Response

Multiple myeloma (MM) is a clonal plasma cell malignancy that develops primarily in the bone marrow (BM), where reciprocal interactions with the BM niche foster MM cell survival, growth, and drug resistance. MM cells furthermore reshape the BM to their own needs by affecting the different BM stromal...

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Bibliographic Details
Main Authors: Eva De Smedt, Hui Lui, Ken Maes, Kim De Veirman, Eline Menu, Karin Vanderkerken, Elke De Bruyne
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
multiple myeloma
epigenetics
histone methyltransferases
histone demethylases
MM cell plasticity
drug response
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00566/full

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