Systemic lidocaine inhibits high-mobility group box 1 messenger ribonucleic acid expression and protein in BALB/c mice after closed fracture musculoskeletal injury

Systemic lidocaine inhibits high-mobility group box 1 messenger ribonucleic acid expression and protein in BALB/c mice after closed fracture musculoskeletal injury

Background: Severe musculoskeletal trauma can trigger an inflammatory response, and an excessive inflammatory response can lead to systemic inflammatory response syndrome and multiorgan failure. High-mobility group box 1 (HMGB1) is an early mediator pro-inflammatory cytokine in sterile injuries and...

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Bibliographic Details
Main Authors: Robert Hotman Sirait, Mochammad Hatta, Muhammad Ramli, Andi Asadul Islam, Syafrie Kamsul Arief
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Saudi Journal of Anaesthesia
Subjects:
Closed fracture; lidocaine; mRNA high-mobility group box 1
Online Access:http://www.saudija.org/article.asp?issn=1658-354X;year=2018;volume=12;issue=3;spage=395;epage=398;aulast=Sirait

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