Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure

Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure

Loss of sensory hair cells from exposure to certain licit drugs (e.g., aminoglycoside antibiotics, platinum-based chemotherapy agents) can result in permanent hearing loss. Here we ask if allosteric activation of the hepatocyte growth factor (HGF) cascade via Dihexa, a small molecule drug candidate,...

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Bibliographic Details
Main Authors: Phillip eUribe, Leen eKawas, Joseph eHarding, Allison eCoffin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Aminoglycosides
Hearing Loss
Hepatocyte Growth Factor
Zebrafish
Lateral Line
Hair Cell Protection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00003/full

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