Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review

Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review

The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as digitalis, have been used to treat heart dise...

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Bibliographic Details
Main Authors: Natalia Słabiak-Błaż, Grzegorz Piecha
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Life
Subjects:
marinobufagenin
ouabain
hypertension
Na/K-ATPase
heart failure
Online Access:https://www.mdpi.com/2075-1729/11/8/727
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spelling doaj-5a23d4d64cad4f3a9bd8ae181649b2832021-08-26T13:58:54ZengMDPI AGLife2075-17292021-07-011172772710.3390/life11080727Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-ReviewNatalia Słabiak-Błaż0Grzegorz Piecha1Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandDepartment of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Francuska 20/24, 40-027 Katowice, PolandThe role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as digitalis, have been used to treat heart disease since ancient times. CTS, also called endogenous digitalis-like factors, take part in the regulation of blood pressure and sodium homeostasis through their effects on the transport enzyme called sodium–potassium adenosine triphosphatase (Na/K-ATPase) in renal and cardiovascular tissue. In recent years, there has been increasing evidence showing deleterious effects of CTS on the structure and function of the heart, vasculature and kidneys. Understanding the role of CTS may be useful in the development of potential new therapeutic strategies.https://www.mdpi.com/2075-1729/11/8/727marinobufageninouabainhypertensionNa/K-ATPaseheart failure
collection DOAJ
language English
format Article
sources DOAJ
author Natalia Słabiak-Błaż
Grzegorz Piecha
spellingShingle Natalia Słabiak-Błaż
Grzegorz Piecha
Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
Life
marinobufagenin
ouabain
hypertension
Na/K-ATPase
heart failure
author_facet Natalia Słabiak-Błaż
Grzegorz Piecha
author_sort Natalia Słabiak-Błaż
title Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
title_short Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
title_full Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
title_fullStr Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
title_full_unstemmed Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review
title_sort endogenous mammalian cardiotonic steroids—a new cardiovascular risk factor?—a mini-review
publisher MDPI AG
series Life
issn 2075-1729
publishDate 2021-07-01
description The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as digitalis, have been used to treat heart disease since ancient times. CTS, also called endogenous digitalis-like factors, take part in the regulation of blood pressure and sodium homeostasis through their effects on the transport enzyme called sodium–potassium adenosine triphosphatase (Na/K-ATPase) in renal and cardiovascular tissue. In recent years, there has been increasing evidence showing deleterious effects of CTS on the structure and function of the heart, vasculature and kidneys. Understanding the role of CTS may be useful in the development of potential new therapeutic strategies.
topic marinobufagenin
ouabain
hypertension
Na/K-ATPase
heart failure
url https://www.mdpi.com/2075-1729/11/8/727
work_keys_str_mv AT nataliasłabiakbłaz endogenousmammaliancardiotonicsteroidsanewcardiovascularriskfactoraminireview
AT grzegorzpiecha endogenousmammaliancardiotonicsteroidsanewcardiovascularriskfactoraminireview
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