The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization

Abstract Background ESCRT-III proteins are involved in many membrane remodeling processes including multivesicular body biogenesis as first discovered in yeast. In humans, ESCRT-III CHMP2 exists as two isoforms, CHMP2A and CHMP2B, but their physical characteristics have not been compared yet. Result...

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Bibliographic Details
Main Authors: Maryam Alqabandi, Nicola de Franceschi, Sourav Maity, Nolwenn Miguet, Marta Bally, Wouter H. Roos, Winfried Weissenhorn, Patricia Bassereau, Stéphanie Mangenot
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Biology
Subjects:
Endosomal sorting complexes Required for Transport (ESCRT)
Reconstituted system
Bottom up approach
Lipid-protein interactions
Membrane
Mechanical properties
Online Access:https://doi.org/10.1186/s12915-021-00983-9

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