Determining of Factors Affecting on Mortality of AIDS Patients by Using Extended Cox Model

• Main Authors: Nasim Karimi, Maliheh Safari, Ghodratollah Roshanaei, Jalal Poorolajal
• Format: Article
• Language: fas
• Published: Arak Medical University 2018-12-01
• Series: Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk
• Subjects: AIDS; Extended cox; HIV; Survival
• Online Access: http://jams.arakmu.ac.ir/article-1-5469-en.pdf
• ISSN: 1735-5338; 2008-644X

Background and Aim: Acquired immunodeficiency syndrome is caused by body contamination with human immunodeficiency virus. Several factors affect the survival of people with AIDS, which are often examined using Cox regression models. The default is to use the Cox model as a proportionate hazard, which in case of a violation, this model does not have the required performance. Therefore, the aim of this study was to determine the effective factors on survival of AIDS patients using the developed Cox model. Materials and Methods: In this cohort study, 1050 patients with AIDS who referred to Imam Khomeini and Zamzam Behavioral Counseling Centers in Tehran Province during the years 2004 to 2014 were studied. The effect of clinical and demographic factors on survival of patients has been investigated using extended Cox model. Findings: 79% of patients were men. The mean age of the patients was 34.84 ± 10. 21 years old. The mean of the diagnosis time to AIDS was 23.64 ± 15.53 months. 76% of patients were cencored. Age at diagnosis, transmission modes, ART, CD4 count, and time to diagnosis of AIDS in univariate and multivariate analysis were significant (p <0.05). Conclusion: Several clinical factors have implications for the survival of AIDS patients. The most important of these factors is the use of ART and early detection of the disease, which greatly increases the chance of survival of the affected population. Therefore, it seems necessary to provide screening and treatment services for high-risk individuals.