THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia

THBS1 regulates trophoblast fusion through a CD36-dependent inhibition of cAMP, and its upregulation participates in preeclampsia

Preeclampsia is a pregnancy complication which threatens the survival of mothers and fetuses. It originates from abnormal placentation, especially insufficient fusion of the cytotrophoblast cells to form the syncytiotrophoblast. In this study, we found that THBS1, a matricellular protein that mediat...

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Bibliographic Details
Main Authors: Fu-Mei Duan, Li-Juan Fu, Yong-Heng Wang, Enoch Appiah Adu-Gyamfi, Ling- Ling Ruan, Zeng-Wei Xu, Shi-Quan Xiao, Xue-Mei Chen, Ying-Xiong Wang, Tai-Hang Liu, Yu-Bin Ding
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Genes and Diseases
Subjects:
cAMP
Cell fusion
Preeclampsia
THBS1
Trophoblast
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304220300726

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