Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment

Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.

Bibliographic Details
Main Authors: Valentina Arkhipova, Albert Guskov, Dirk J. Slotboom
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14834-8
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spelling doaj-5a15e2c8a0a34570bdd68f209b8447e02021-05-11T08:56:30ZengNature Publishing GroupNature Communications2041-17232020-02-011111910.1038/s41467-020-14834-8Structural ensemble of a glutamate transporter homologue in lipid nanodisc environmentValentina Arkhipova0Albert Guskov1Dirk J. Slotboom2Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of GroningenGroningen Biomolecular Sciences and Biotechnology Institute (GBB), University of GroningenGroningen Biomolecular Sciences and Biotechnology Institute (GBB), University of GroningenGlutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.https://doi.org/10.1038/s41467-020-14834-8
collection DOAJ
language English
format Article
sources DOAJ
author Valentina Arkhipova
Albert Guskov
Dirk J. Slotboom
spellingShingle Valentina Arkhipova
Albert Guskov
Dirk J. Slotboom
Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
Nature Communications
author_facet Valentina Arkhipova
Albert Guskov
Dirk J. Slotboom
author_sort Valentina Arkhipova
title Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_short Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_full Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_fullStr Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_full_unstemmed Structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
title_sort structural ensemble of a glutamate transporter homologue in lipid nanodisc environment
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-02-01
description Glutamate transporters are membrane transporters that clear the neurotransmitter L-glutamate from the synaptic cleft via a so-called elevator mechanism. Here the authors present five cryo-EM structures of the transporter homologue GltTk, which explain how substrate leakage is prevented.
url https://doi.org/10.1038/s41467-020-14834-8
work_keys_str_mv AT valentinaarkhipova structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment
AT albertguskov structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment
AT dirkjslotboom structuralensembleofaglutamatetransporterhomologueinlipidnanodiscenvironment
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