Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

Novel biodegradable protonic ionic liquid for the Fischer indole synthesis reaction

Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amou...

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Bibliographic Details
Main Authors: William C. Neuhaus, Ian J. Bakanas, Joseph R. Lizza, Charles T. Boon, Gustavo Moura-Letts
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Green Chemistry Letters and Reviews
Subjects:
Ionic liquids
indole
Fischer indole synthesis
tetramethylguanidinium
biodegradable
Online Access:http://dx.doi.org/10.1080/17518253.2016.1149231
Description
Summary:Novel eco-friendly tetramethylguanidinium propanesulfonic acid trifluoromethylacetate ([TMGHPS][TFA]) ionic liquid was developed as catalyst and medium for the Fischer indole synthesis of a wide variety of hydrazines and ketones. The indole products were isolated in high yields and with minimal amounts of organic solvent. This reaction showed that [TMGHPS][TFA] can be regenerated and reused with reproducible yields without eroding the integrity of the ionic liquid.
ISSN:1751-8253
1751-7192

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