A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib.

A new method for the study of biophysical and morphological parameters in 3D cell cultures: Evaluation in LoVo spheroids treated with crizotinib.

Three-dimensional (3D) culture systems like tumor spheroids represent useful in vitro models for drug screening and more broadly for cancer biology research, but the generation of uniform populations of spheroids remains challenging. The possibility to properly characterize spheroid properties would...

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Bibliographic Details
Main Authors: Azzurra Sargenti, Francesco Musmeci, Carola Cavallo, Martina Mazzeschi, Simone Bonetti, Simone Pasqua, Francesco Bacchi, Giuseppe Filardo, Daniele Gazzola, Mattia Lauriola, Spartaco Santi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0252907

Internet

https://doi.org/10.1371/journal.pone.0252907

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