Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction

Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction

Objective(s):Our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(TGF-β1), α-smooth muscle actin (α-SMA) and alleviating interstitial fibrosis following unilateral ureteral obstruction (UUO). In this study, we investigate...

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Main Authors: Yang Mei, Zhuang Yangyang, Luo Shuai, Jin Hao, Yang Yirong, Cai Yong, Xia Peng, Chen Bicheng, Zhang Yan
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2016-05-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Antioxidant
Biological properties
HPLC
RSM
Stachys parviflora L
UAE
Online Access:http://ijbms.mums.ac.ir/article_6943_2f21c7cc6919793983d8d7190c6cdb99.pdf
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spelling doaj-5a05e5c73a904aa9bb2bd4c1774068d92020-11-24T23:16:31ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742016-05-011955735786943Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstructionYang Mei0Zhuang Yangyang1Luo Shuai2Jin Hao3Yang Yirong4Cai Yong5Xia Peng6Chen Bicheng7Zhang Yan8Department of Intensive Care Unit, The First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Intensive Care Unit, The First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaKey Laboratory of Surgery, Department of Surgery, The First Affiliated Hospital of Wenzhou Medicine University, ChinaDepartment of Transplantation Center, the First Affiliate Hospital of Wenzhou Medicine University, ChinaObjective(s):Our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(TGF-β1), α-smooth muscle actin (α-SMA) and alleviating interstitial fibrosis following unilateral ureteral obstruction (UUO). In this study, we investigate the effect of breviscapine on changes of renal water and sodium transport proteins in response to UUO. Materials and Methods: Male Sprague-Dawley rats were divided into 3 groups, sham group, UUO group and UUO treat with breviscapine. After 4, 7 and 14 days, histologic changes and interstitial collagen were determined microscopically following hematoxylin and eosin (H&E) and Masson's trichrome staining. The expression of Aquaporins (AQP-2) and γ-epithelial sodium channel (γ-ENaC) were investigated using immunohistochemistry and Western blot in each group. Results:Breviscapine treatment decrease the tubular injury index and the degree of interstitial collagen deposition significantly compared with the UUO group (Phttp://ijbms.mums.ac.ir/article_6943_2f21c7cc6919793983d8d7190c6cdb99.pdfAntioxidantBiological propertiesHPLCRSMStachys parviflora LUAE
collection DOAJ
language English
format Article
sources DOAJ
author Yang Mei
Zhuang Yangyang
Luo Shuai
Jin Hao
Yang Yirong
Cai Yong
Xia Peng
Chen Bicheng
Zhang Yan
spellingShingle Yang Mei
Zhuang Yangyang
Luo Shuai
Jin Hao
Yang Yirong
Cai Yong
Xia Peng
Chen Bicheng
Zhang Yan
Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
Iranian Journal of Basic Medical Sciences
Antioxidant
Biological properties
HPLC
RSM
Stachys parviflora L
UAE
author_facet Yang Mei
Zhuang Yangyang
Luo Shuai
Jin Hao
Yang Yirong
Cai Yong
Xia Peng
Chen Bicheng
Zhang Yan
author_sort Yang Mei
title Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
title_short Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
title_full Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
title_fullStr Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
title_full_unstemmed Breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
title_sort breviscapine prevents downregulation of renal water and sodium transport proteins in response to unilateral ureteral obstruction
publisher Mashhad University of Medical Sciences
series Iranian Journal of Basic Medical Sciences
issn 2008-3866
2008-3874
publishDate 2016-05-01
description Objective(s):Our recent report indicates that breviscapine play a protective role of the kidney by down-regulating transforming growth factor-β1(TGF-β1), α-smooth muscle actin (α-SMA) and alleviating interstitial fibrosis following unilateral ureteral obstruction (UUO). In this study, we investigate the effect of breviscapine on changes of renal water and sodium transport proteins in response to UUO. Materials and Methods: Male Sprague-Dawley rats were divided into 3 groups, sham group, UUO group and UUO treat with breviscapine. After 4, 7 and 14 days, histologic changes and interstitial collagen were determined microscopically following hematoxylin and eosin (H&E) and Masson's trichrome staining. The expression of Aquaporins (AQP-2) and γ-epithelial sodium channel (γ-ENaC) were investigated using immunohistochemistry and Western blot in each group. Results:Breviscapine treatment decrease the tubular injury index and the degree of interstitial collagen deposition significantly compared with the UUO group (P
topic Antioxidant
Biological properties
HPLC
RSM
Stachys parviflora L
UAE
url http://ijbms.mums.ac.ir/article_6943_2f21c7cc6919793983d8d7190c6cdb99.pdf
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AT zhuangyangyang breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT luoshuai breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT jinhao breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT yangyirong breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT caiyong breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT xiapeng breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT chenbicheng breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
AT zhangyan breviscapinepreventsdownregulationofrenalwaterandsodiumtransportproteinsinresponsetounilateralureteralobstruction
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