The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes

The Vacuolar Pathway in Macrophages Plays a Major Role in Antigen Cross-Presentation Induced by the Pore-Forming Protein Sticholysin II Encapsulated Into Liposomes

Cross-presentation is an important mechanism for the differentiation of effector cytotoxic T lymphocytes (CTL) from naïve CD8+ T-cells, a key response for the clearance of intracellular pathogens and tumors. The liposomal co-encapsulation of the pore-forming protein sticholysin II (StII) with ovalbu...

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Bibliographic Details
Main Authors: Yoelys Cruz-Leal, Daniel Grubaugh, Catarina V. Nogueira, Isbel Lopetegui-González, Anaixis del Valle, Felipe Escalona, Rady J. Laborde, Carlos Alvarez, Luis E. Fernández, Michael N. Starnbach, Darren E. Higgins, María E. Lanio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
antigen cross-presentation
dendritic cells
liposomes
macrophages
sticholysin II
pore-forming protein
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02473/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02473/full

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