Comparison of post cesarean infection after single dose versus three doses of prophylactic antibiotic regimen

• Main Authors: Farnaz Mohammadian, Ahmadreza Mobaien
• Format: Article
• Language: English
• Published: Bushehr University of Medical Sciences 2013-04-01
• Series: Iranian South Medical Journal
• Subjects: cesarean; infection; prophylactic antibiotic; cefazolin
• Online Access: http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-310&slc_lang=en&sid=1

Background: Cesarean delivery is a surgical operation which is applied to prevent maternal and fetal complications. Cesarean delivery isn’t without complication and has some complications such as infection. Postoperative infection includes endometritis, wound infection and septic pelvic thrombophlebitis that depend to prophylactic antibiotics and surgical technique. The aim of this study was comparison of post operative infection after single dose and three doses of prophylactic antibiotic regimens. . Material and Methods: This double blind randomized clinical trial was performed on all pregnant women referd to the Vali-Asr Hospital of Zanjan University of Medical Sciences and underwent cesarean delivery during one year from starting study. Participants subsequently were randomized into two groups: A (recieved single dose of prophylactic antibiotic) and B (recieved three doses of prophylactic antibiotic). Subjects were checked up for the clinical signs of infection during hospitalization and 10 days after discharge. The results were analyzed by SPSS Software Ver16 and Chi-Square Test. Results: During one year, 146 pregnant women with cesarean delivery entered 2 equal groups (A and B) which each group had 73 subjects. During hospitalization after cesarean delivery, 5(6.8%) patients of group A and 2(2.7%) patients of group B had fever. There was no significant correlation between the two groups. Conclusion: There was no significant correlation between single dose and three doses of prophylactic antibiotic regimens in groups A and B. Therefore, it seems thatthere is no need to use three doses of prophylactic antibiotic for cesarean delivery.Therfore, because of drug resistance and economic loss, single dose of prophylactic antibiotic is recommended for prevention of post cesarean infection