HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development

HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development

Trithorax proteins and long-intergenic noncoding RNAs are critical regulators of embryonic stem cell pluripotency; however, how they cooperatively regulate germ layer mesoderm specification remains elusive. We report here that HoxBlinc RNA first specifies Flk1+ mesoderm and then promotes hematopoiet...

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Bibliographic Details
Main Authors: Changwang Deng, Ying Li, Lei Zhou, Joonseok Cho, Bhavita Patel, Naohiro Terada, Yangqiu Li, Jörg Bungert, Yi Qiu, Suming Huang
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Cell Reports
Subjects:
HoxBlinc lincRNA
SETD1A and MLL1 HMTs
hoxb gene activation
chromatin looping
mesoderm specification
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715014199

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