TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh
Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-14183-1 |
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doaj-59e9f9ce370048ddbeca2a29123f847a2021-05-11T08:29:32ZengNature Publishing GroupNature Communications2041-17232020-01-0111111510.1038/s41467-019-14183-1TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and XdhLimin Zhao0Hao Ke1Haibo Xu2Guo-Dong Wang3Honglei Zhang4Li Zou5Shu Xiang6Mengyuan Li7Li Peng8Mingfang Zhou9Lingling Li10Lei Ao11Qin Yang12Che-Kun James Shen13Ping Yi14Lu Wang15Baowei Jiao16State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesThe First Hospital of Kunming, Calmette International HospitalDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical UniversityYubei District Maternal and Child Health Care HospitalDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical UniversityState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesKunming Angel Women’s and Children’s HospitalState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesInstitute of Molecular Biology, Academia SinicaDepartment of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical UniversityState Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan, Yunnan UniversityState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesMilk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability.https://doi.org/10.1038/s41467-019-14183-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Limin Zhao Hao Ke Haibo Xu Guo-Dong Wang Honglei Zhang Li Zou Shu Xiang Mengyuan Li Li Peng Mingfang Zhou Lingling Li Lei Ao Qin Yang Che-Kun James Shen Ping Yi Lu Wang Baowei Jiao |
| spellingShingle |
Limin Zhao Hao Ke Haibo Xu Guo-Dong Wang Honglei Zhang Li Zou Shu Xiang Mengyuan Li Li Peng Mingfang Zhou Lingling Li Lei Ao Qin Yang Che-Kun James Shen Ping Yi Lu Wang Baowei Jiao TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh Nature Communications |
| author_facet |
Limin Zhao Hao Ke Haibo Xu Guo-Dong Wang Honglei Zhang Li Zou Shu Xiang Mengyuan Li Li Peng Mingfang Zhou Lingling Li Lei Ao Qin Yang Che-Kun James Shen Ping Yi Lu Wang Baowei Jiao |
| author_sort |
Limin Zhao |
| title |
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh |
| title_short |
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh |
| title_full |
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh |
| title_fullStr |
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh |
| title_full_unstemmed |
TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh |
| title_sort |
tdp-43 facilitates milk lipid secretion by post-transcriptional regulation of btn1a1 and xdh |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Milk lipid secretion is a critical process for the delivery of nutrition and energy from parent to offspring. Here the authors found that TDP-43, a RNA-binding protein, is required for milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh mRNA stability. |
| url |
https://doi.org/10.1038/s41467-019-14183-1 |
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