Degradation Behavior of Polymers Used as Coating Materials for Drug Delivery—A Basic Review

• Main Authors: Anita Ioana Visan, Gianina Popescu-Pelin, Gabriel Socol
• Format: Article
• Language: English
• Published: MDPI AG 2021-04-01
• Series: Polymers
• Subjects: degradation; biopolymers; thin films; in vitro characterization techniques; bioreactor
• Online Access: https://www.mdpi.com/2073-4360/13/8/1272

The purpose of the work was to emphasize the main differences and similarities in the degradation mechanisms in the case of polymeric coatings compared with the bulk ones. Combined with the current background, this work reviews the properties of commonly utilized degradable polymers in drug delivery, the factors affecting degradation mechanism, testing methods while offering a retrospective on the evolution of the controlled release of biodegradable polymeric coatings. A literature survey on stability and degradation of different polymeric coatings, which were thoroughly evaluated by different techniques, e.g., polymer mass loss measurements, surface, structural and chemical analysis, was completed. Moreover, we analyzed some shortcomings of the degradation behavior of biopolymers in form of coatings and briefly proposed some solving directions to the main existing problems (e.g., improving measuring techniques resolution, elucidation of complete mathematical analysis of the different degradation mechanisms). Deep studies are still necessary on the dynamic changes which occur to biodegradable polymeric coatings which can help to envisage the future performance of synthesized films designed to be used as medical devices with application in drug delivery.