Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation

Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation

An overdose of the most popular analgesic, acetaminophen (APAP), is one of the leading causes of acute liver failure. It is well established that glutathione is exhausted by APAP-reactive intermediate N‑acetyl‑p‑benzoquinone-imine (NAPQI). This leads to elevated phosphorylated-c-Jun N-terminal kinas...

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Bibliographic Details
Main Authors: Apu Chowdhury, Jihong Lu, Rumeng Zhang, Jahan Nabila, Hang Gao, Zhikang Wan, Isaac Adelusi Temitope, Xiaoxing Yin, Ying Sun
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Acetaminophen
Liver failure
Mangiferin
APAP-Cys
JNK
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219314763

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http://www.sciencedirect.com/science/article/pii/S0753332219314763

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