Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

Studies have shown that the process of extracellular vesicles (EVs) secretion and lysosome status are linked. When the lysosome is under stress, the cells would secrete more EVs to maintain cellular homeostasis. However, the process that governs lysosomal activity and EVs secretion remains poorly de...

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Bibliographic Details
Main Authors: Chee Fan Tan, Hui San Teo, Jung Eun Park, Bamaprasad Dutta, Shun Wilford Tse, Melvin Khee-Shing Leow, Walter Wahli, Siu Kwan Sze
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
extracellular vesicles
extracellular vesicles biogenesis
pulsed-SILAC
hypothalamus
energy homeostasis
cathepsin
Online Access:https://www.mdpi.com/2073-4409/9/5/1320

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