Protective effects of the selective alpha1A-adrenoceptor antagonist silodosin against cyclophosphamide-induced cystitis in rats

Protective effects of the selective alpha1A-adrenoceptor antagonist silodosin against cyclophosphamide-induced cystitis in rats

We investigated the protective effects of a selective α1A-adrenoceptor antagonist, silodosin (Silod) on urinary bladder function in cyclophosphamide (CYP)-induced cystitis rats, with and without desensitization of the capsaicin (CAP)-sensitive afferent nerve pathway. Male Wistar rats (310–400 g) wer...

Full description

Bibliographic Details
Main Authors:	Nanxi Liu, Shogo Shimizu, Takahiro Shimizu, Kumiko Nakamura, Masaki Yamamoto, Youichirou Higashi, Motoaki Saito
Format:	Article
Language:	English
Published:	Elsevier 2016-09-01
Series:	Journal of Pharmacological Sciences
Subjects:	Afferent nerve pathway Alpha 1A-adrenoceptor antagonist Cyclophosphamide-induced cystitis Intercontraction interval Silodosin
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861316301141

Similar Items

Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia
by: Yoshida M, et al.
Published: (2011-06-01)

Managing a side effect: Cyclophosphamide-induced hemorrhagic cystitis
by: Bhavana Ravindra Doshi, et al.
Published: (2019-01-01)

The Potential of Asiatic Acid in the Reversion of Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats
by: Andrzej Wróbel, et al.
Published: (2021-05-01)

Effect of Lycopene on Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats
by: Akram Jamshidzadeh, et al.
Published: (2009-03-01)

Hyperbaric oxygen-A new horizon in treating cyclophosphamide-induced hemorrhagic cystitis
by: S Ajith Kumar, et al.
Published: (2011-01-01)

Pharmacological and histopathological study of cyclophosphamide-induced hemorrhagic cystitis - comparison of the effects of dexamethasone and Mesna
by: M.M. Morais, et al.
Published: (1999-10-01)

High-definition ultrasound characterization of acute cyclophosphamide-induced cystitis in the mouse
by: Toy G. Lee, et al.
Published: (2020-01-01)

Successful management of severe refractory haemorrhagic cystitis secondary to cyclophosphamide and BK virus with cystotomy and alum infusion
by: Gerald Mak, et al.
Published: (2021-11-01)

Cyclophosphamide-induced intractable hemorrhagic cystitis treated with hyperbaric oxygenation and intravesical sodium hyaluronate
by: Chuo-Jung Tsai, et al.
Published: (2014-12-01)

Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
by: Shogo Shimizu, et al.
Published: (2015-01-01)

Hemorrhagic cystitis in children treated with alkylating agent cyclophosphamide: The experience of a medical center in Taiwan
by: Ching-Chia Wang, et al.
Published: (2015-08-01)

Downregulation of tight junction protein zonula occludens-2 and urothelium damage in a cyclophosphamide-induced mouse model of cystitis
by: Yung-Hsiang Chen, et al.
Published: (2018-06-01)

Simultaneous estimation of silodosin and silodosin β-D-glucuronide in human plasma using LC-MS/MS for a pharmacokinetic study
by: Siva Sankara Rao Yadlapalli, et al.
Published: (2018-07-01)

Severe Hemorrhagic Cystitis Caused by Cyclophosphamide and Capecitabine Therapy in Breast Cancer Patients: Two Case Reports and Literature Review
by: Toshihiro Tanaka, et al.
Published: (2019-01-01)

Cyclophosphamide administration routine in autoimmune rheumatic diseases: a review
by: Kaian Amorim Teles, et al.

Medical expulsive therapy for distal ureteric stones: tamsulosin versus silodosin
by: Vittorio Imperatore, et al.
Published: (2014-06-01)

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice
by: Masahiro Murakami-Nakayama, et al.
Published: (2015-02-01)

Platelet-Rich Plasma Ameliorates Cyclophosphamide-Induced Acute Interstitial Cystitis/Painful Bladder Syndrome in a Rat Model
by: Yung-Hsiang Chen, et al.
Published: (2020-06-01)

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α1A/α1D-Adrenergic Receptor Antagonist with Potential Uroselective Profile
by: Vittorio Canale, et al.
Published: (2018-08-01)

Efficacy and safety of silodosin, vardenafil versus silodosin in combination with vardenafil as a medical expulsive therapy for distal ureteric stones: a prospective randomized double-blind study
by: Mohamed Samir, et al.
Published: (2020-07-01)

Urine uromodulin estimation in partial bladder outlet obstruction and cyclophosphamide-induced haemorrhagic cystitis models in rats
by: Łukasz Dobrek, et al.
Published: (2014-09-01)

Comparative analysis of clinical effectiveness of α1-adrenoblockers doxazosin, tamsulosin and silodosin in males with chronic non-inflammatory prostatitis
by: A O Lobkarev, et al.
Published: (2018-12-01)

Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: A mouse cyclophosphamide-induced model of cystitis
by: Okinami, Takeshi
Published: (2015)

Characterization and Validation of a Chronic Model of Cyclophosphamide-Induced Interstitial Cystitis/Bladder Pain Syndrome in Rats
by: Céline Augé, et al.
Published: (2020-08-01)

Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome
by: Luke Grundy, et al.
Published: (2018-12-01)

Investigation of ejaculatory disorder by silodosin in the treatment of prostatic hyperplasia
by: Sakata Koichi, et al.
Published: (2012-10-01)

Comparison of transurethral incision of the prostate and silodosin in patients having benign prostatic obstruction in terms of retrograde ejaculation
by: Basri Cakiroglu, et al.
Published: (2017-03-01)

Improvement in Near Vision Following Silodosin Treatment in Patients With Lower Urinary Tract Symptoms
by: Hyun Jin Shin, et al.
Published: (2021-06-01)

Safety of Cyclophosphamide Therapy in Autoimmune Rheumatic Diseases
by: Ramaswamy Subramanian, et al.
Published: (2019-01-01)

Protective effect of simvastatin in the cyclophosphamide-induced hemohrragic cystitis in rats Efeito protetor da sinvastatina na cistite hemorrágica induzida pela ciclofosfamida em ratos
by: Anna Carolina Batista Dantas, et al.
Published: (2010-02-01)

Assessment of therapeutic effect of human choriogonadotropin in a chemical cystitis model
by: Serhat Tanik, et al.
Published: (2017-05-01)

The utility of hyperbaric oxygen therapy in post-transplant cyclophosphamide-induced hemorrhagic cystitis: a case report and review of the literature
by: Moayed Ibrahim, et al.
Published: (2021-01-01)

Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis
by: Bhavik Patel, et al.
Published: (2020-02-01)

Expression of Caveolin-1 in Rat Urinary Bladder with Cyclophosphamide-Induced Cystitis
by: Sun-Ouck Kim, et al.
Published: (2012-12-01)

Evaluation of static and dynamic Pupillometry changes in men using Silodosin for benign prostatic hypertrophy
by: Umut Karaca, et al.
Published: (2021-03-01)

THE EFFECT OF SILODOSIN AND SODIUM DICLOFENAC TO REDUCE PAIN AFTER DJ STENT REMOVAL IN SOETOMO HOSPITAL: DOUBLE-BLINDED RANDOMIZED-CONTROLLED TRIAL
by: Hasroni Fathurrahman, et al.
Published: (2019-01-01)

A histopathological evaluation on the effect of captopril in cyclophosphamide-induced hemorrhagic cystitis
by: Nahid Ahmadi, et al.
Published: (2021-03-01)

Emphysematous cystitis
by: D Rommel, et al.
Published: (2012-05-01)

Ketamine-snorting associated cystitis
by: Chung-Hsien Chen, et al.
Published: (2011-12-01)

The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers
by: Mallory Batty, et al.
Published: (2016-08-01)