Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit

Validation of a novel animal model for sciatic nerve repair with an adipose-derived stem cell loaded fibrin conduit

Despite the regenerative capabilities of peripheral nerves, severe injuries or neuronal trauma of critical size impose immense hurdles for proper restoration of neuro-muscular circuitry. Autologous nerve grafts improve re-establishment of connectivity, but also comprise substantial donor site morbid...

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Bibliographic Details
Main Authors: Maximilian M Saller, Rosa-Eva Huettl, Julius M Mayer, Annette Feuchtinger, Christian Krug, Thomas Holzbach, Elias Volkmer
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Neural Regeneration Research
Subjects:
critical-size nerve defect; fibrin conduit; autologous nerve transplant; peripheral nerve regeneration; adipose-derived stem/progenitor cells; sciatic function index; sciatic nerve; re-innervation; axon guidance; peripheral circuitry
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2018;volume=13;issue=5;spage=854;epage=861;aulast=Saller

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