Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory

Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory

Memory consolidation theory suggests that memory is maintained at a stable strength after formation. The authors show that memory is dynamically maintained at an intermediate level allowing a bidirectional regulation which is mediated by a balance between activated Rac1 and expressed α2-chimaerin.

Bibliographic Details
Main Authors: Li Lv, Yunlong Liu, Jianxin Xie, Yan Wu, Jianjian Zhao, Qian Li, Yi Zhong
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13236-9
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spelling doaj-59b7addfb29a49d7a3e66465766dc4a32021-05-11T11:41:11ZengNature Publishing GroupNature Communications2041-17232019-11-0110111210.1038/s41467-019-13236-9Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memoryLi Lv0Yunlong Liu1Jianxin Xie2Yan Wu3Jianjian Zhao4Qian Li5Yi Zhong6Peking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityPeking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityNational Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of SciencesPeking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityPeking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityPeking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityPeking University-Tsinghua University-National Institute Biological Science Joint Graduate Program, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua UniversityMemory consolidation theory suggests that memory is maintained at a stable strength after formation. The authors show that memory is dynamically maintained at an intermediate level allowing a bidirectional regulation which is mediated by a balance between activated Rac1 and expressed α2-chimaerin.https://doi.org/10.1038/s41467-019-13236-9
collection DOAJ
language English
format Article
sources DOAJ
author Li Lv
Yunlong Liu
Jianxin Xie
Yan Wu
Jianjian Zhao
Qian Li
Yi Zhong
spellingShingle Li Lv
Yunlong Liu
Jianxin Xie
Yan Wu
Jianjian Zhao
Qian Li
Yi Zhong
Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
Nature Communications
author_facet Li Lv
Yunlong Liu
Jianxin Xie
Yan Wu
Jianjian Zhao
Qian Li
Yi Zhong
author_sort Li Lv
title Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
title_short Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
title_full Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
title_fullStr Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
title_full_unstemmed Interplay between α2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
title_sort interplay between α2-chimaerin and rac1 activity determines dynamic maintenance of long-term memory
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-11-01
description Memory consolidation theory suggests that memory is maintained at a stable strength after formation. The authors show that memory is dynamically maintained at an intermediate level allowing a bidirectional regulation which is mediated by a balance between activated Rac1 and expressed α2-chimaerin.
url https://doi.org/10.1038/s41467-019-13236-9
work_keys_str_mv AT lilv interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT yunlongliu interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT jianxinxie interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT yanwu interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT jianjianzhao interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT qianli interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
AT yizhong interplaybetweena2chimaerinandrac1activitydeterminesdynamicmaintenanceoflongtermmemory
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