Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

Novel endogenous N-acyl amides activate TRPV1-4 receptors, BV-2 microglia, and are regulated in brain in an acute model of inflammation

A family of endogenous lipids, structurally analogous to the endogenous cannabinoid, N-arachidonoyl ethanolamine (Anandamide), and called N-acyl amides have emerged as a family of biologically active compounds at TRP receptors. N-acyl amides are constructed from an acyl group and an amine via an ami...

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Bibliographic Details
Main Authors: Siham eRaboune, Jordyn M Stuart, Emma eLeishman, Sara M Takacs, Brandon eRhodes, Arjun eBasnet, Evan eJameyfield, Douglas eMcHugh, Theodore eWidlanski, Heather Bryte Bradshaw
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Endocannabinoids
Microglia
lipid signaling
N-acyl amides
TRP receptors
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00195/full

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