Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Cartilage-binding antibodies initiate joint inflammation and promote chronic erosive arthritis

Abstract Background Antibodies binding to cartilage proteins are present in the blood and synovial fluid of early rheumatoid arthritis patients. In order to develop animal models mimicking the human disease, we have characterized the arthritogenic capacity of monoclonal antibodies directed towards d...

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Bibliographic Details
Main Authors: Yanpeng Li, Dongmei Tong, Peibin Liang, Erik Lönnblom, Johan Viljanen, Bingze Xu, Kutty Selva Nandakumar, Rikard Holmdahl
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Cartilage
Animal models
Antibodies
Collagen
Online Access:http://link.springer.com/article/10.1186/s13075-020-02169-0

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