Modulation of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice

Modulation of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells Ameliorates Surgical Stress-Induced Atherosclerotic Plaque Progression in ApoE-Deficient Mice

Systemic inflammation associated with major surgery rapidly accelerates atherosclerotic plaque progression in mice. Regulatory T cells (Tregs) have emerged as important modulators of atherogenesis. In coronary artery disease patients, low frequency of Tregs constitutes an independent risk factor for...

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Bibliographic Details
Main Authors: Jessica Handke, Laura Kummer, Markus A. Weigand, Jan Larmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
atherosclerosis
regulatory T cells
inflammation
perioperative stress response
plaque vulnerability
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.682458/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.682458/full

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