HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Thioredoxin-interacting protein (Txnip) inhibits the activity of thioredoxin (Trx) to modulate inflammatory responses. The burden of inflammation caused by microbial infection is strongly associated with disease severity; however, the role of Txnip in bacterial infection remains unclear. In Group A...

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Bibliographic Details
Main Authors: Po-Chun Tseng, Chih-Feng Kuo, Miao-Huei Cheng, Shu-Wen Wan, Chiou-Feng Lin, Chih-Peng Chang, Yee-Shin Lin, Jiunn-Jong Wu, Chi-Chen Huang, Chia-Ling Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
group A Streptococcus
Txnip
TLR2
itch
ubiquitination
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02147/full

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