Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.

Bibliographic Details
Main Authors:	Xiaolu Ma, Hongmei Liu, Jing Li, Yihao Wang, Yue-He Ding, Hongyan Shen, Yeran Yang, Chenyi Sun, Min Huang, Yingfeng Tu, Yang Liu, Yongliang Zhao, Meng-Qiu Dong, Ping Xu, Tie-Shan Tang, Caixia Guo
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-02164-1

id	doaj-599494d1f24f4a00a4388d28f4e28b0b
record_format	Article
spelling	doaj-599494d1f24f4a00a4388d28f4e28b0b2021-05-11T07:14:24ZengNature Publishing GroupNature Communications2041-17232017-12-018111410.1038/s41467-017-02164-1Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesisXiaolu Ma0Hongmei Liu1Jing Li2Yihao Wang3Yue-He Ding4Hongyan Shen5Yeran Yang6Chenyi Sun7Min Huang8Yingfeng Tu9Yang Liu10Yongliang Zhao11Meng-Qiu Dong12Ping Xu13Tie-Shan Tang14Caixia Guo15CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of SciencesBeijing Key Laboratory of DNA Damage Response, College of Life Sciences, Capital Normal UniversityState Key Laboratory of Proteomics National Center for Protein Sciences Beijing, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, Beijing Institute of Radiation MedicineNational Institute of Biological Sciences (Beijing)CAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesState Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesNational Institute of Biological Sciences (Beijing)State Key Laboratory of Proteomics National Center for Protein Sciences Beijing, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, Beijing Institute of Radiation MedicineState Key Laboratory of Membrane Biology, Institute of Zoology, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, University of Chinese Academy of Sciences, Chinese Academy of SciencesPolη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.https://doi.org/10.1038/s41467-017-02164-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xiaolu Ma Hongmei Liu Jing Li Yihao Wang Yue-He Ding Hongyan Shen Yeran Yang Chenyi Sun Min Huang Yingfeng Tu Yang Liu Yongliang Zhao Meng-Qiu Dong Ping Xu Tie-Shan Tang Caixia Guo
spellingShingle	Xiaolu Ma Hongmei Liu Jing Li Yihao Wang Yue-He Ding Hongyan Shen Yeran Yang Chenyi Sun Min Huang Yingfeng Tu Yang Liu Yongliang Zhao Meng-Qiu Dong Ping Xu Tie-Shan Tang Caixia Guo Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis Nature Communications
author_facet	Xiaolu Ma Hongmei Liu Jing Li Yihao Wang Yue-He Ding Hongyan Shen Yeran Yang Chenyi Sun Min Huang Yingfeng Tu Yang Liu Yongliang Zhao Meng-Qiu Dong Ping Xu Tie-Shan Tang Caixia Guo
author_sort	Xiaolu Ma
title	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_short	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_full	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_fullStr	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_full_unstemmed	Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis
title_sort	polη o-glcnacylation governs genome integrity during translesion dna synthesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-12-01
description	Polη is a key player in translesion DNA synthesis. Here, the authors uncover that, in response to DNA damage, Polη undergoes O-GlcNAcylation at threonine 457 by O-GlcNAc transferase to facilitate the timely disassembly of Polη after DNA lesion bypass.
url	https://doi.org/10.1038/s41467-017-02164-1
work_keys_str_mv	AT xiaoluma polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT hongmeiliu polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT jingli polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yihaowang polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yueheding polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT hongyanshen polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yeranyang polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT chenyisun polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT minhuang polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yingfengtu polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yangliu polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT yongliangzhao polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT mengqiudong polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT pingxu polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT tieshantang polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis AT caixiaguo polēoglcnacylationgovernsgenomeintegrityduringtranslesiondnasynthesis
_version_	1721452574079451136

Polη O-GlcNAcylation governs genome integrity during translesion DNA synthesis

Similar Items