Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study

Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study

Introduction: There is currently a lack of translatable, preclinical models of low back pain (LBP). Chymopapain, a proteolytic enzyme used to treat lumbar intervertebral disc (IVD) herniation, could induce discogenic LBP. The current study developed a behavioral model of discogenic LBP in nonhuman p...

Full description

Bibliographic Details
Main Authors: Hiroki Ushirozako, Go Yoshida, Daisuke Togawa, Takao Omura, Tomohiko Hasegawa, Yu Yamato, Tomohiro Banno, Hideyuki Arima, Shin Oe, Yuki Mihara, Tomohiro Yamada, Takahiro Natsume, Shinya Ogawa, Yuji Awaga, Hiroyuki Takamatsu, Yukihiro Matsuyama
Format: Article
Language:English
Published: The Japanese Society for Spine Surgery and Related Research 2019-10-01
Series:Spine Surgery and Related Research
Subjects:
chymopapain
discogenic low back pain
nonhuman primate
pressure test
brain activation
functional magnetic resonance imaging
secondary somatosensory cortex
insular cortex
Online Access:https://www.jstage.jst.go.jp/article/ssrr/3/4/3_2018-0110/_pdf/-char/en

Similar Items

Similar Items