Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity

The presence of Fusobacterium nucleatum (F. nucleatum) in the gut is associated with the development of colorectal cancer (CRC). F. nucleatum promotes tumor development by inducing inflammation and host immune response in the CRC microenvironment. Adhesion to the intestinal epithelium by the cell su...

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Main Authors:	Jiao Wu, Qing Li, Xiangsheng Fu
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	Translational Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523319300233

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spelling	doaj-5987c4f4120f40d0bf19a1767e11ec1c2020-11-24T21:23:55ZengElsevierTranslational Oncology1936-52332019-06-01126846851Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host ImmunityJiao Wu0Qing Li1Xiangsheng Fu2Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Sichuan, China, 646000Department of Gastroenterology, the Affiliated Hospital of Southwest Medical University, Sichuan, China, 646000Department of Gastroenterology, the Affiliated Hospital of North Sichuan Medical College, Nanchong City, China, 637000; Address all correspondence to: Dr. Xiangsheng Fu, Department of Gastroenterology, the Affiliated Hospital of North Sichuan Medical College, Road Wenhua 63#, Region Shunqing, Nanchong City, China, 637000.The presence of Fusobacterium nucleatum (F. nucleatum) in the gut is associated with the development of colorectal cancer (CRC). F. nucleatum promotes tumor development by inducing inflammation and host immune response in the CRC microenvironment. Adhesion to the intestinal epithelium by the cell surface proteins FadA, Fap2 and RadD expressed by F. nucleatum can cause the host to produce inflammatory factors and recruit inflammatory cells, creating an environment which favors tumor growth. Furthermore, F. nucleatum can induce immune suppression of gut mucosa by suppressing the function of immune cells such as macrophages, T cells and natural killer cells, contributing the progression of CRC.http://www.sciencedirect.com/science/article/pii/S1936523319300233
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jiao Wu Qing Li Xiangsheng Fu
spellingShingle	Jiao Wu Qing Li Xiangsheng Fu Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity Translational Oncology
author_facet	Jiao Wu Qing Li Xiangsheng Fu
author_sort	Jiao Wu
title	Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
title_short	Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
title_full	Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
title_fullStr	Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
title_full_unstemmed	Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity
title_sort	fusobacterium nucleatum contributes to the carcinogenesis of colorectal cancer by inducing inflammation and suppressing host immunity
publisher	Elsevier
series	Translational Oncology
issn	1936-5233
publishDate	2019-06-01
description	The presence of Fusobacterium nucleatum (F. nucleatum) in the gut is associated with the development of colorectal cancer (CRC). F. nucleatum promotes tumor development by inducing inflammation and host immune response in the CRC microenvironment. Adhesion to the intestinal epithelium by the cell surface proteins FadA, Fap2 and RadD expressed by F. nucleatum can cause the host to produce inflammatory factors and recruit inflammatory cells, creating an environment which favors tumor growth. Furthermore, F. nucleatum can induce immune suppression of gut mucosa by suppressing the function of immune cells such as macrophages, T cells and natural killer cells, contributing the progression of CRC.
url	http://www.sciencedirect.com/science/article/pii/S1936523319300233
work_keys_str_mv	AT jiaowu fusobacteriumnucleatumcontributestothecarcinogenesisofcolorectalcancerbyinducinginflammationandsuppressinghostimmunity AT qingli fusobacteriumnucleatumcontributestothecarcinogenesisofcolorectalcancerbyinducinginflammationandsuppressinghostimmunity AT xiangshengfu fusobacteriumnucleatumcontributestothecarcinogenesisofcolorectalcancerbyinducinginflammationandsuppressinghostimmunity
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Fusobacterium nucleatum Contributes to the Carcinogenesis of Colorectal Cancer by Inducing Inflammation and Suppressing Host Immunity

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