MicroRNA-17-92 Regulates Beta-Cell Restoration After Streptozotocin Treatment

MicroRNA-17-92 Regulates Beta-Cell Restoration After Streptozotocin Treatment

Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair after streptozotocin intervention.Methods: Genetically engineered mice (miR-17-92βKO) and control RIP-Cre mice were intraperitoneally injected with multiple low dose streptozotocin. Body weight, random blood...

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Bibliographic Details
Main Authors: Shan Wan, Jie Zhang, Xiang Chen, Jiangli Lang, Li Li, Fei Chen, Li Tian, Yang Meng, Xijie Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Endocrinology
Subjects:
miR-17-92 cluster
pancreatic beta-cells
streptozotocin
restoration
Cdkn1a
ATM kinase
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00009/full

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