Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro

Background. Hypercholesterolemia and disruptions of the blood brain barrier (BBB) have been implicated as underlying mechanisms in the pathogenesis of Alzheimer's disease (AD). Simvastatin therapy may be of benefit in treating AD; however, its mechanism has not been yet fully understood. Object...

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Bibliographic Details
Main Authors:	Xijuan Jiang, Maojuan Guo, Jinling Su, Bin Lu, Dongming Ma, Ruifeng Zhang, Lin Yang, Qiang Wang, Yiwen Ma, Yingchang Fan
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	International Journal of Alzheimer's Disease
Online Access:	http://dx.doi.org/10.1155/2012/109324

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